What to consider when buying baby prebiotics

  • Human Milk Oligosaccharides

    Bio-identical to those found in breast milk, HMOs promote healthy gut flora and immune development

  • Inulin

    A prebiotic fiber from chicory root and encourages growth of probiotics like bifidobacteria and lactobacilli

  • Extra ingredients

    All baby formulas must meet the same basic nutritional requirements. Some include extra nutrients like DHA, ARA, and prebiotics

  • Organic

    Organic products are important to both adults & babies, especially when choosing between dairy-based formula from cow or goat milk

Editor's note: Because of supply chain issues and recalls, formula shortages are affecting many families. For advice on switching and which formulas are currently in stock, see our article Coping With the Baby Formula Shortage? Here's How to Swap Brands.

Top 5 Best Prebiotics for Infants (0–12 Months) in 2025

Prebiotics play a key role in supporting infant gut health by feeding beneficial bacteria. While breast milk naturally contains prebiotics like HMOs, many formula-fed or mixed-fed infants can benefit from standalone prebiotic supplements. In 2025, several safe, effective, and pediatrician-approved options are available in the U.S. Below are the top five standalone prebiotic supplements for infants, ranked based on ingredients, clinical support, parent reviews, and ease of use.

Granola Baby's #1 Choice for value & nutrition

1. Begin Health BeginBaby Prebiotic + Probiotic

BeginBaby by Begin Health is a synbiotic supplement specially formulated for infants ages 0–12 months. It combines 2’-FL HMO, the most abundant prebiotic in human milk, with two clinically studied probiotic strains: Bifidobacterium infantis and B. lactis. This blend is designed to mimic the beneficial gut-nourishing components of breast milk, making it suitable for both breastfed and formula-fed infants. Developed in collaboration with pediatric experts, BeginBaby is easy to mix, free from common allergens, and has quickly become a parent favorite for its ability to ease tummy issues and support gut balance from an early age.

Key Product Info:

  • Contains 2’-FL HMO plus two infant-specific probiotic strains.
  • Clinically shown to ease colic, fussiness, and digestive issues.
  • Safe, allergen-free formula developed with pediatric experts.
  • Dissolves easily in milk or formula with no flavor.
  • Highly rated by parents for reducing constipation and gas.
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Solid CHoice for Prebiotics

2. Biostime 2’-FL HMO Prebiotic + Vitamin D Powder

Biostime’s HMO powder is a clean, straightforward option for parents looking to supplement their baby’s gut health with a breast milk-inspired prebiotic. Each serving contains 2’-FL, an HMO identical to those found in human milk, along with 400 IU of Vitamin D3, eliminating the need for a separate vitamin D supplement. Designed for infants and toddlers, this product is ideal for formula-fed babies who may be missing out on natural prebiotic exposure. It’s easy to mix into bottles, has no taste or odor, and is well-tolerated even by sensitive stomachs.

Key Product Info:

  • Mimics breast milk by adding 2’-FL to infant diets.
  • Eases gas, constipation, and digestive discomfort gently.
  • Includes Vitamin D3 for immune and bone support.
  • Allergen-free and easy to mix into bottles.
  • Often used with probiotics for enhanced gut balance.
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Affordable Pricing

3. Lovebug Tiny Tummies Prebiotic + Probiotic (6–12 months)

Lovebug’s Tiny Tummies is a USDA Organic synbiotic designed for infants 6–12 months, offering a thoughtful mix of prebiotics and probiotics in one daily packet. It features five well-researched probiotic strains, including B. infantis and L. rhamnosus GG, and includes added prebiotic fiber to fuel good bacteria growth. Created by a mom-founded brand with a commitment to clean, allergen-free formulas, Tiny Tummies is designed to relieve digestive issues like colic, reflux, and irregular stools. It’s especially helpful during times of dietary transition, such as starting solids or recovering from antibiotics.

Key Product Info:

  • Combines prebiotics with probiotics in a USDA Organic formula.
  • Targets common infant issues like colic, reflux, and eczema.
  • No sugar, allergens, or artificial ingredients.
  • Tasteless and easy-to-use daily powder packets.
  • Parent-approved with top safety and quality ratings.
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Great For Babies with Sensitive Stomachs

4. UpSpring Probiotic + Colostrum Powder (with Prebiotics)

UpSpring’s Probiotic + Colostrum supplement takes a multi-functional approach to infant wellness. It includes six probiotic strains, prebiotic fiber, and bovine colostrum, rich in natural antibodies, to support both digestive comfort and immune development. This powder is particularly popular among parents whose babies have frequent tummy troubles or have recently taken antibiotics. By combining probiotics and colostrum in one formula, it helps restore gut balance while offering additional protection during infancy’s most vulnerable stages. The product is made in the U.S. and is free from sugars, fillers, and synthetic ingredients.

Key product info:

  • Contains 6 probiotic strains plus prebiotic fiber and colostrum.
  • Supports both digestive health and immunity.
  • Designed to relieve constipation, gas, and diarrhea.
  • Free from added sugars and artificial ingredients.
  • Colostrum adds antibody and immune-supporting benefits.
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Easiest Prebiotic to Use

5. Bio-Kult Infantis Probiotic Sachets (with Prebiotic FOS)

Bio-Kult Infantis is a well-rounded probiotic and prebiotic formula developed by microbiologists and trusted by healthcare providers. It includes seven live probiotic strains that are microencapsulated for optimal delivery to the gut, as well as FOS (a plant-based prebiotic) and a gentle dose of Vitamin D3. Suitable for babies 6 months and older, this powder is ideal for daily maintenance or use during antibiotic recovery. Parents love its shelf-stable format, easy mixability, and strong safety record, especially for infants who need broad-spectrum gut support without refrigeration.

Key product info:

  • Multi-strain formula with added prebiotic and Vitamin D3.
  • Supports digestion, immunity, and post-antibiotic recovery.
  • Shelf-stable, tasteless, and travel-friendly powder sachets.
  • No refrigeration needed and safe for daily use.
  • Highly rated by health-conscious parents and clinicians.
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In conclusion...

Each of these infant-safe prebiotic supplements offers a unique blend of benefits depending on your baby's needs—whether it's mimicking the components of breast milk, relieving tummy troubles, or strengthening immunity. As always, consult your pediatrician before introducing any supplement, but rest assured these five options are among the most trusted and effective on the market in 2025.

Our Featured Baby Formula

Made from fresh whole goat milk, our beautiful baby formulas and toddler milk support gentle digestion for little tummies - with less processing and more natural goodness. Goat milk is a rich source of nutrients with naturally occurring A2 casein, oligosaccharides and prebiotics.

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